Tramadol Offers Relief For Extreme Cancer Pain

One can buy Tramadol to provide relief to patients suffering from cancer. Two different categories of analgesics are generally Tramadol for the treatment of cancer patients. Tramadol Tramadol Short acting and acting are the two types of medicine. The shorter are used for immediate relief and already used for pain relief around the clock. Tramadol plays the role of enhancing the levels of norepinephrine and serotonin, thereby reducing the body's ability to feel pain. The effects of different tramadols are different. Little effect tramadols has a 3 to 4 hours and sustain the action models of pain longer decreased until approximately 24 hours.

You can also buy Tramadol in patients suffering from osteoarthritis. For shorter acting, Tramadol pain relief can be provided by having a 50 mg tablet. The extended-release tablets come in different doses as 100 mg, 200 mg or 300 mg. Tablets should be taken as a whole, not chewing or division, for better pain relief tramadol. After buying Tramadol should be taken in accordance with the guidelines of the physician to avoid side effects of medication. Wrong dosage of tramadol may result in serious damage to the body, including death.

Tramadol should be avoided because they are mothers, and mothers in breastfeeding. Tramadol use in this period is uncertain, as it can lead to complications in the baby inside. The excessive use of medication can lead to dependency, so it is best not to use the medication without consulting your doctor. Some temporary side effects like nausea, dizziness, dry mouth, pruritus, etc. can be seen at times due to the use of tramadol. Tramadol overdose can also lead to neurological disorders in the patient which leads to thoughts of suicide or the like.

New Discovery to fight Cancer

In the last week was published in the journal Virtual Network San Diego, Madrid, a news report about a new discovery in cancer treatments. Apparently human tumor cells may be destroyed with a material that generates electric fields to be lit, which could lead to future cancer treatment based phototherapy.

This discovery is the result of research involving biologists and physicists from the Autonomous University of Madrid (UAM), said today that Spanish institution in a statement.

Research has shown that, in laboratory culture conditions, it is possible to eliminate human tumor cells using lithium niobate doped with iron, a material that generates significant electric field when illuminated with light.

So far, this material had not been used in biomedicine, but this finding has generated two patent applications to develop a drug for cancer phototherapy, which would administer nanoparticles of this material and illuminate the tumor with visible light.

The researchers grew human tumor cells on lithium niobate crystals doped with iron and examined their behavior in different light conditions.

They noted that these cancer cells proliferated while kept in the dark, but they died "within minutes" when exposed to light.

According to San Diego Red, in other experiments, tumor cells were exposed to microparticles of the material and, as the Spanish university, the results were "virtually identical", but had to increase the exposure to light.

Copyright by San Diego Network

Strawberries may prevent cancer of the esophagus

Esophageal cancer is the third most common gastrointestinal cancer and the sixth among the major killer of cancer in the world. The researchers studied the squamous cell carcinoma (SCC) of the esophagus that is 95 percent of cases of esophageal cancer worldwide.

Participants consumed 60 grams of freeze-dried strawberries daily for six months and completed a dietary diary about their consumption of strawberries. The use of lyophilized strawberries was important because by removing water from fruits multiplied by ten concentration preventive substances.

The researchers obtained biopsy specimens before and after consumption of strawberries. The results showed that 29 of the 36 participants experienced a decrease in histological grade of precancerous lesions during the study.

"Our study is important because it shows that strawberries may slow the progression of precancerous lesions in the esophagus. The strawberries could be an alternative or work together with other drugs quemopreventivos to prevent esophageal cancer. But we will need in future trials prove "concluded Chen.

Increased intake of vitamin D may Reduce Cancer Risk

According to HealthDay News study on 27 February notes that more vitamin D than previously thought to dramatically reduce the risk of several serious diseases, including breast cancer. "We found that adults need to consume daily between 4.000 and 8.000 IU to maintain blood levels of vitamin D metabolites in the range needed to reduce the risk of several diseases such as breast cancer, colon cancer, multiple sclerosis and diabetes Type 1, in the middle, "said study co-author Dr. Cedric Garland, professor of family and preventive medicine at the University of California at San Diego, in a press release from the university. Garland admitted he was surprised that the required levels were much higher than 400 IU a day needed to overcome rickets in the twentieth century. Vitamin D supplements often come in pills or capsules containing between 1,000 and 2,000 international units. But taking between 4,000 and 8,000 IU per day is still much lower than the range considered safe by the National Academy of Sciences' Institute of Medicine, the researchers said. The study, which also involved the faculty of medicine at Creighton University in Omaha, was based on a survey of several thousand people who took supplements ranging from 1.000 to 10.000 IU per day. The volunteers also underwent blood tests to determine levels of vitamin D metabolites circulating in the blood. Some studies suggest that only 10 percent of the U.S. population has the appropriate level as related to vitamin D in the blood that prevents disease associated with a deficiency of this vitamin. They tend to work outside, so their vitamin D levels increase with sun exposure. Last year, a committee of the National Academy of Sciences and the Institute of Medicine (IOM) announced to take 4.000 IU daily of vitamin D appears safe for adults and children ages 9 and older. However, the daily minimum level recommended by the IOM is 600 IU, the Institute also noted that there were early signs that there might be some harm associated with consuming high levels of vitamin D a day, even in amounts below the recommended upper limit as insurance. Garland and his colleagues suggested that 4,000 IU per day is a safe level. "Now that we have the results of this study, taking 4000 IU a day will become commonplace for most adults," predicted Garland in the press release. "This is below the 10,000 IU per day that the IOM Committee Report considers as the lower limit of risk, and the benefits are substantial."

Delay Of Childbearing Increases The Risk Of Breast Cancer

Studies claim that delaying the arrival of the first child is a predisposing factor for the development of this tumor. A leading specialist explained why this happens and how to prevent disease.
Breast cancer is a major cause of death in women worldwide. Because of this, throughout the world are carried out prevention campaigns, trying to get conscious about the importance of routine consultation the specialist to avoid developing the disease.

Nevertheless, beyond the annual realization of complete gynecological studies, there are social factors that influence the onset of the disease. Within this group is of motherhood.

The prestigious Italian physician Umberto Veronesi, surgeon breast cancer and founder of the European Institute of Oncology, spoke with Infobae.com about the negative consequences wrought by the arrival of a child as it is currently facing.

He explained that in the world the incidence of breast cancer increased because, in general, the postponement of motherhood.

"Women now have a greater risk, and the reasons are having fewer children and pregnancy protects against breast tumors. Also, start having children at older ages ", which also negatively affected, said Veronesi.

In that sense, he specified that "women when they have young children do not have breast tumors, as has the number of children also suffer."

Other factors that influence the development of the disease is feeding the baby, more and more away from the natural and closer to the milk bottles and industrialized. "Now breastfeeding is very low, contributing to this increase," said the specialist.

The key: early detection

Veronesi said that "by failing to apply preventive therapies, science has focused on the early diagnosis of this disease."

In this regard, noted the current use of mammography, ultrasound through ultrasound and magnetic resonance imaging, which allow "detect tumors up to five millimeters in diameter" very effectively.

"The right age to start this type of screening at age 30 with ultrasound, the woman over 40, getting mammograms, and those with genetic background or considers its genetic test or placed within a group high risk should begin before the age of 20 should get an MRI every five years ", stated the doctor.

Then, it is essential that women take charge of their breast health. To Veronesi, the best way is based on three simple steps:

1 - That each knows best or depth within it.

2 - To recognize that this is an illness, which cured if detected early and the kills if it is discovered late.

3 - I fight this with optimism, determination and will. "Many times the woman discovers or suspects that may have this disease and pretend they do not, so delay its consideration. And with that all you are doing is aggravating the situation, "he said.

"Women are the ones now in hand to manage this situation. It's not a problem in medicine is a problem of the woman is the one to use to make the diagnosis early, "he concluded Veronesi.

Research Explains How Some Viruses Cause Cancer

According to the results of a study published in Genome Research, led by Manel Esteller, director of the Epigenetics and Biology as the results of a study published in Genome Research, led by Manel Esteller, director of the Epigenetics and Cancer Biology Biomedical Research Institute (IDIBELL) and Institute of Oncology (ICO) and ICREA researcher, says that 15% of cancer cases are related to virus. But not all infected people eventually develop a malignant tumor. The malignant process is initiated in cases where the pathogen is able to modify their own genetic material to outwit the body's defenses.
Researchers analyzed more than 500 tissue samples infected by major oncogenic viruses: human papilloma virus, necessary cause for the occurrence of cervical cancer, the hepatitis B virus, related to the occurrence of liver cancer, and Epstein-Barr virus, the cause of some types of lymphoma. They have been collected in three population groups: those infected but not symptomatic, people who have developed an infection or a malignant lesion, and people who have already developed a tumor or cancer associated.

In each of these stages, the genetic material of the virus undergoes important changes in the epigenome. That is, the pattern of chemical signals, a kind of switches, which makes their genes (genome) are expressed or not. Methylation of the disabled, and acetylation activates them. "When the virus enters the body, in the early stages of infection, is expressed in all their genes because it is not methylated. So the immune system can detect and remove it," says Esteller.

But gradually, the virus manages to evade the immune system. As the infection progresses to a premalignant state, the virus are still more methylated, which means that their genes are expressed and leaving, therefore, the immune system it is increasingly costing attack detection and said Esteller. The virus achieves this state by robbing the host cell proteins. The uses to weave a garment with which disguise biochemical immune system. However, it hides your viral load, which is still active. When the malignant tumor appears, the virus has not only fully camouflaged, but the genetic spoliation has also modify the behavior of the cell and turn it into a carcinogen.

What makes these viruses increase their ability to deceive? To get an accurate answer still need more research, but there are indications that on the one hand individual genetic differences influence. And other studies indicate that some environmental exposures facilitate methylation. This is the case of exposure to snuff, to high radiation doses or excesses in the sun, says Esteller. Bad habits not only alter the epigenetics of the virus, but also weaken the immune system and make it easier for viruses to penetrate better into the cell. In fact, when it detects the presence of hepatitis B and C are used drugs that enhance immune system activity. In the case of papilloma virus (HPV), there is still no effective treatment to destroy it, but advises extreme healthy habits so that the immune system to defend itself in the most effective and runs with it, explains Silvia Sanjose, responsible Unit of Infections and Cancer ICO. In women, HPV is a 55% of the tumor-associated infections.

According to both experts, knowing the epigenetics of these viruses will develop treatments that prevent methylation, ie they prevent the virus robs its host cell proteins to trick the immune system. Esteller believes that these alterations may also be present in other viruses responsible for diseases such as influenza and AIDS.

Other research shows that not only inherits the genome, but their pattern of activation, the epigenome. "We believe the epigenome altered by toxic habits could also be inherited," he concludes.

New Genetic Regions Active In Cancer

Cancer Center researchers at Massachusetts General Hospital, USA, have discovered that certain DNA sequences, known as 'satellite repeat', experience a massive overexpression when they appear in the tumors. The investigation of this phenomenon is an important step in better diagnosis and understanding of cancer.
"The satellite repeats make up a large part of our genome, but were thought to be inactive," says David Ting, a researcher at the Massachusetts Cancer Center and co-author. However, this research developed new techniques for sequencing, shows that these regions are very active in cancer.

Researchers have found that overexpression of satellite repeats starts early in tumor development, so it is essential to achieve early detection in the patient. To carry out the study, researchers have used a digital gene expression analysis called "single molecule sequencing of next generation."

Possible cancer biomarker

With this system, they demonstrated, in a mouse pancreatic cancer, the satellite DNA was expressed at levels exceeding 100 times the values ​​recorded in normal tissues. On the other hand, when analyzing samples of epithelial cancer (the most common type of tumor) was found both in colon tumors as lung, mouse repeated the same levels.

"Our hope is that this anomaly (hitherto unknown) serve as a biomarker in cancer diagnosis and shed light on the mechanisms by which tumors develop," says Daniel Haber, director of the Cancer Center and lead author.

The study in human cancer cells obtained similar results in most cancers studied, including tumors of the pancreas, lung and prostate. If confirmed in prospective clinical trials, "the satellite RNA expression may provide a new and highly specific biomarker related to several types of epithelial cancers," he says Ting.